Search results for "spatial statistic"
showing 10 items of 18 documents
Minimum contrast for point processes' first-order intensity estimation
2023
In this paper, we exploit some theoretical results, from which we know the expected value of the K-function weighted by the true first-order intensity function of a point pattern. This theoretical result can serve as an estimation method for obtaining the parameter estimates of a specific model, assumed for the data. The only requirement is the knowledge of the first-order intensity function expression, completely avoiding writing the likelihood, which is often complex to deal with in point process models. We illustrate the method through simulation studies for spatio-temporal point processes.
An autoregressive approach to spatio-temporal disease mapping
2007
Disease mapping has been a very active research field during recent years. Nevertheless, time trends in risks have been ignored in most of these studies, yet they can provide information with a very high epidemiological value. Lately, several spatio-temporal models have been proposed, either based on a parametric description of time trends, on independent risk estimates for every period, or on the definition of the joint covariance matrix for all the periods as a Kronecker product of matrices. The following paper offers an autoregressive approach to spatio-temporal disease mapping by fusing ideas from autoregressive time series in order to link information in time and by spatial modelling t…
Some contributions in disease mapping modeling
2020
Disease mapping ha recibido un gran interés durante las tres últimas décadas. Esta área de investigación persigue el estudio de la distribución geográfica de eventos relacionados con la salud, tales como la mortalidad o la incidencia de enfermedades, agregados en unidades geográficas, con el fin de identificar principalmente aquellas localizaciones que presentan un mayor riesgo. La aplicación de métodos estadísticos avanzados para llevar a cabo las estimaciones de los riesgos resulta fundamental para obtener estimaciones precisas y profundizar en el entendimiento de la distribución geográfica de las enfermedades. En esta tesis nos centramos en la aplicación y evaluación de varias propuestas…
Mapping age- and sex-specific HIV prevalence in adults in sub-Saharan Africa, 2000–2018
2022
Abstract Background Human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) is still among the leading causes of disease burden and mortality in sub-Saharan Africa (SSA), and the world is not on track to meet targets set for ending the epidemic by the Joint United Nations Programme on HIV/AIDS (UNAIDS) and the United Nations Sustainable Development Goals (SDGs). Precise HIV burden information is critical for effective geographic and epidemiological targeting of prevention and treatment interventions. Age- and sex-specific HIV prevalence estimates are widely available at the national level, and region-wide local estimates were recently published for adults overall. We…
Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immun…
2020
Simple Summary The introduction of immune-checkpoint inhibitors improved the therapeutic landscape for patients with advanced malignant melanoma. However, many patients, including patients with melanoma brain metastases, do not derive benefit from immune-checkpoint blockade. Hence, biomarkers are needed to identify potential mechanisms of resistance and optimize patient selection. This study aimed to explore the role of hypoxia-mediated immunosuppression within the tumor microenvironment of patients with metastatic melanoma using multiplex immunofluorescence. We analyzed the prognostic relevance of the hypoxia surrogate marker GLUT-1, the adenosine-synthesizing ectoenzymes CD73/CD39, and th…
Linking Microstructural Integrity and Motor Cortex Excitability in Multiple Sclerosis
2021
Motor skills are frequently impaired in multiple sclerosis (MS) patients following grey and white matter damage with cortical excitability abnormalities. We applied advanced diffusion imaging with 3T magnetic resonance tomography for neurite orientation dispersion and density imaging (NODDI), as well as diffusion tensor imaging (DTI) in 50 MS patients and 49 age-matched healthy controls to quantify microstructural integrity of the motor system. To assess excitability, we determined resting motor thresholds using non-invasive transcranial magnetic stimulation. As measures of cognitive-motor performance, we conducted neuropsychological assessments including the Nine-Hole Peg Test, Trail Makin…
Physical activity, aerobic fitness, and brain white matter : Their role for executive functions in adolescence
2020
Highlights • Aerobic fitness level, but not physical activity, is related to white matter properties in the brain. • The relation between physical activity and working memory is moderated by fractional anisotropy (FA) of the corpus callosum. • The FA of the corpus callosum and superior corona radiata moderates the relation between aerobic fitness and working memory.
Advances in blind source separation for spatial data
2021
Viele Datensaetze bestehen aus multivariaten Messungen, die an verschiedenen geographischen Orten durchgefuehrt wurden. Typischerweise besitzen solche Datensaetze die Eigenschaft, dass Messungen in unmittelbarer Naehe aehnlicher sind als Messungen, die eine hohe Entfernung aufweisen. In der statistischen Analyse solcher raeumlichen Daten sollte diese spezielle Eigenschaft beruecksichtigt werden. In letzter Zeit wurde in der statistischen Literatur die sogenannte Blind Source Separation Methode auf raeumliche Daten erweitert. In diesem Model wird angenommen, dass die Daten aus Linearkombinationen von unbeobachteten Variablen bestehen, und das Ziel ist diese latenten Variablen zu bestimmen. D…
Blind source separation for non-stationary random fields
2022
Regional data analysis is concerned with the analysis and modeling of measurements that are spatially separated by specifically accounting for typical features of such data. Namely, measurements in close proximity tend to be more similar than the ones further separated. This might hold also true for cross-dependencies when multivariate spatial data is considered. Often, scientists are interested in linear transformations of such data which are easy to interpret and might be used as dimension reduction. Recently, for that purpose spatial blind source separation (SBSS) was introduced which assumes that the observed data are formed by a linear mixture of uncorrelated, weakly stationary random …
On the convenience of heteroscedasticity in highly multivariate disease mapping
2019
Highly multivariate disease mapping has recently been proposed as an enhancement of traditional multivariate studies, making it possible to perform the joint analysis of a large number of diseases. This line of research has an important potential since it integrates the information of many diseases into a single model yielding richer and more accurate risk maps. In this paper we show how some of the proposals already put forward in this area display some particular problems when applied to small regions of study. Specifically, the homoscedasticity of these proposals may produce evident misfits and distorted risk maps. In this paper we propose two new models to deal with the variance-adaptiv…